终点HBsAg定量与普通干扰素治疗慢性乙肝停药1年内复发的相关性分析

Correlation analysis of terminal HBsAg quantity and the recurrence within 1 year of chronic hepatitis b treated with ordinary interferon

目的:比较治疗终点(停药)HBs Ag定量,分析终点HBs Ag定量与普通干扰素治疗慢性乙肝1年内复发的相关性。方法:2009年1月-2013年6月收治慢性乙型肝炎患者90例,分为复发组和无复发组,比较两组停药时HBs Ag定量的不同。结果:复发组停药时HBs Ag定量较高,两组比较差异具有统计学意义(P<0.05)。结论:普通干扰素治疗慢性乙肝达到治疗终点时HBs Ag定量的高低与停药后1年内复发率存在明显的正相关性。普通干扰素治疗慢性乙型肝炎停药时HBs Ag的水平是推断治疗后1年内复发的有效预测指标。

Objective:To compare the treatment terminal HBsAg quantity and analyze the correlation of terminal HBsAg quantity and the recurrence within 1 year of chronic hepatitis b treated with ordinary interferon.Methods:90 cases of patients with chronic hepatitis b from January 2009 to June 2013 were divided into the relapse group and the no-relapse group and the differences of HBsAg quantity in the two groups were compared.Results:The terminal HBsAg quantity of the relapse group was higher,there was statistically significant difference between the two groups(P<0.05).Conclusion:The terminal HBsAg quantity of chronic hepatitis b treated by ordinary interferon had obviously positive correlation with the recurrence rate within 1 year.The terminal HBsAg quantity of chronic hepatitis b treated by ordinary interferon was inferred effective predictors of recurrence within 1 year after treatment.