奈达铂联合氟尿嘧啶与顺铂联合氟尿嘧啶治疗老年晚期食管癌效果的对比观察

Comparison of curative effect of nedaplatin combined with 5-fluorouracil and cisplatin combined with 5-fluorouracil in the treatment of elderly patients with advanced esophageal cancer

目的:对比奈达铂(NDP)联合氟尿嘧啶(5-FU)与顺铂(DDP)联合氟尿嘧啶治疗老年晚期食管癌的效果和不良反应。方法:收治老年晚期食管癌患者46例,随机分为NDP+5-FU治疗组(A组,24例)和DDP+5-FU对照组(B组,22例),比较两组患者的疗效和不良反应。结果:A组总有效率27.53%,B组总有效率22.73%(P<0.05)。A组主要不良反应为骨髓抑制,B组主要不良反应为消化道反应。结论:奈达铂治疗老年晚期食管癌患者的效果显著,不良反应小。

Objective:To explore the curative effect and adverse reactions of nedaplatin combined with 5-fluorouracil andcisplatin combined with 5-fluorouracil in the treatment of elderly patients with advanced esophageal cancer.Methods:46 elderlypatients with advanced esophageal cancer were selected,they were randomly divided into NDP+5-FU treatment group(A group,24cases) and DDP+5-FU control group(B group,22 cases),we compared the efficacy and adverse reactions of the two groups.Results:The total effective rate in the A group was 27.53%,and the total effective rate in the B group was 22.73%(P<0.05).In the A group,the main adverse reactions were bone marrow suppression,in the B group,the main adverse reactions were gastrointestinalreactions.Conclusion:Effect of nedaplatin in the treatment of elderly patients with advanced esophageal carcinoma was significant,adverse reaction was small.