呼吸兴奋剂剂量对慢性阻塞性肺疾病急性加重期患者治疗效果的影响

Effect of respiratory stimulants dose on the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease

目的:探究呼吸兴奋剂剂量和时间对慢性阻塞性肺疾病(COPD)急性加重期患者的治疗效果。方法:收治COPD急性加重期患者64例,均实施无创呼吸机辅助通气治疗的基础上根据呼吸兴奋剂尼可刹米的剂量均分成两组,对照组每24 h静脉注射1次尼可刹米,1.125 g/次,观察组每12 h静脉注射1次尼可刹米,1.125 g/次,对其治疗效果展开探讨。结果:从血气指标方面分析,观察组显著优于对照组(P<0.05),证明该方案能够显著纠正患者的p H值,提高氧分压,降低二氧化碳分压。结论:临床上建议对COPD急性加重期患者选择呼吸兴奋剂剂量为1.125 g/12h的方案,改善患者缺氧状态,促进二氧化碳排出,提高生存质量。

Objective:To investigate the respiratory stimulants dose and time on the treatment of patients with acute exacerbationof chronic obstructive pulmonary disease.Methods:64 patients with acute exacerbation of chronic obstructive pulmonary diseasewere selected.According to the respiratory stimulant of nikethamide doses they were divided into the two groups on the basis of theimplementation of noninvasive ventilator assisted ventilation.The control group was taken intravenous nikethamide 1 times every24 hours,1.125 g/times,while the observation group was taken intravenous nikethamide 1 times every 12 hours,1.125 g/times.Thetreatment effect was discussed.Results:From the aspect of blood gas analysis,the observation group was significantly better thanthe control group(P<0.05), which is proved that the proposed method can significantly correct the pH value of the patients,increasethe oxygen partial pressure,reduce the partial pressure of carbon dioxide.Conclusion:Clinical recommendations for the respiratorystimulants dose on the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease:1.125 g/12h of the program,improve the patients with hypoxia,promote the discharge of carbon dioxide,improve the quality of life.