弥可保序贯治疗带状疱疹后神经痛的临床效果及安全性研究

Study on the clinical efficacy and safety of methycobal sequential therapy in the treatment of patients with post-herpetic neuralgia

目的:探讨弥可保序贯治疗带状疱疹后神经痛的临床效果及安全性。方法:收治带状疱疹后遗神经痛患者128例,随机平分为弥可保序贯组(A组)、弥可保静脉滴注组(B组)、弥可保肌内注射(C组)和口服组(D组),治疗后观察4组的临床疗效、不良反应情况。结果:弥可保序贯组治疗有效率显著高于弥可保肌内注射组及口服组(P<0.05)。弥可保序贯组中出现一过性头晕1例,静脉滴注组中出现一过性恶心1例,肌内注射组中出现一过性臀部麻痛1例,均不影响后续治疗。序贯组治疗费用低于弥可保静脉滴注组。结论:对于带状疱疹后神经痛患者,弥可保序贯疗效好,安全性高,费用低。

Objective:To explore the clinical efficacy and safety of methycobal sequential therapy in the treatment of patients withpost-herpetic neuralgia.Methods:128 patients with post-herpetic neuralgia were selected,they were randomly divided into themethycobal sequential group(A group),the methycobal intravenous group(B group),the mecobalamin intramuscular injection(Cgroup)and the oral group(D group).We observed the clinical efficacy and adverse reactions of the 4 groups after treatment.Results:The effective rate of the methycobal sequential group was significantly higher than that of the mecobalamin intramuscularinjection group and the oral group(P<0.05).There was 1 case of transient dizziness in the methycobal sequential group,1 case oftransient nausea in the intravenous drip group,we observed 1 case of transient pain and numbness of hip in the intramuscularinjection group,but had no effect on the subsequent treatment.The treatment cost of the sequential group is lower than themethycobal intravenous group.Conclusion:For patients with post-herpetic neuralgia,the effect of methycobal sequential therapy isgood with high safety and low cost.