类风湿因子和抗环瓜氨酸肽抗体在不同年龄段类风湿关节炎中的诊断价值

Diagnostic value of rheumatoid factor and anti-cyclic citrullinated peptide antibody in rheumatoid arthritis in different ages

目的：探讨类风湿因子(RF)和抗环瓜氨酸肽抗体(anti-CCP)在不同年龄段类风湿关节炎(RA)患者中的诊断价值。方法：收治类风湿关节炎患者1017例，回顾性分析其临床资料。结果：RF和anti-CCP在RA患者中的阳性率分别为62.8%和58.9%。这两者抗体阳性率在16～40岁与40～60岁，40～60岁与＞60岁之间的差异无统计学意义。然而，这两种抗体在＜16岁的RA患者中的阳性率显著低于＞16岁的患者。结论：RF联合anti-CCP检测有助于成人RA患者的临床诊断，其诊断价值显著优于青少年RA。

Objective:To explore the diagnostic value of rheumatoid factor(RF) and anti-cyclic citrullinated peptideantibody(anti-CCP) in rheumatoid arthritis(RA) in different ages.Methods:1 017 patients with rheumatoid arthritis were selected,the clinical data were retrospectively analyzed.Results:The positive rates of RF and anti-CCP in patients with rheumatoid arthritiswere 62.8% and 58.9% respectively.The positive rate of two kinds of antibodies between 16 to 40 years old and 40 to 60 years oldand between 40 to 60 years old and over 60 years old was not statistically different.However,the positive rate of two kinds ofantibodies in patients with rheumatoid arthritis less than 16 years old was significantly lower than that of patients over 16 yearsold.Conclusion:RF combined with anti-CCP detection was helpful to the clinical diagnosis of adult RA patients,and its diagnosticvalue was significantly better than that of teen RA.