大剂量前列地尔治疗重度黄疸型病毒性肝炎的临床疗效

The clinical efficacy of large dose of alprostadil in the treatment of severe icteric viral hepatitis

目的:分析大剂量前列地尔治疗重度黄疸型病毒性肝炎的临床疗效。方法:收治重度黄疸型病毒性肝炎患者107例,分设为对照组47例与研究组60例,对照组予以还原型谷胱甘肽、甘草酸二胺以及茵栀黄常规药物医治,研究组于此基础上增用大剂量前列地尔药物医治,比对两组肝功能指标以及不良反应情况。结果:研究组肝功能指标优于对照组,差异具有统计学意义(P<0.05)。结论:患者行还原型谷胱甘肽、甘草酸制剂以及茵栀黄联合前列地尔药物医治可改善肝功能指标,无明显不良反应。

Objective:To analyze the clinical efficacy of large dose of alprostadil in the treatment of severe icteric viral hepatitis.Methods:107 patients with severe icteric viral hepatitis were selected.They were divided into the control group with 47 cases and the study group with 60 cases.The control group was given glutathione,diammonium glycyrrhizinate and Yinzhihuang conventional drug treatment,while the research group was treated with high dose of alprostadil drug on the basis of the control group.The liver function indexes and adverse reactions of the two groups were compared.Results:The liver function index of the study group was significantly better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Patients treated by glutathione,diammonium glycyrrhizinate and Yinzhihuang combined with alprostadil can improve liver function index,with no significant adverse reactions.