不同剂量辛伐他汀治疗老年高血压合并高脂血症的临床疗效及安全性探讨

Discussion on the clinical curative effect and safety of different doses of simvastatin in the treatment of elderly patients with hypertension and hyperlipidemia

目的:探讨不同剂量辛伐他汀治疗老年高血压合并高脂血症的临床疗效及安全性。方法:收治老年高血压合并高脂血症患者54例,按照使用辛伐他汀药物剂量不同分为两组。对照组给予20 mg/d辛伐他汀治疗,观察组给予40 mg/d辛伐他汀治疗。观察两组患者治疗效果,并就两组患者血脂各项指标进行比较。结果:观察组和对照组治疗总有效率、不良反应比较,差异有统计学意义(P<0.05)。观察组TC、TG及LDL-C指标均显著低于对照组(P<0.05)。结论:针对老年高血压合并高脂血症患者建议使用40 mg/d剂量的辛伐他汀进行治疗,不但能快速改善患者血脂情况,且不良反应较少。

Objective:To discuss the clinical curative effect and safety of different doses of simvastatin in the treatment of elderlypatients with hypertension and hyperlipidemia.Methods:54 elderly patients with hypertension and hyperlipidemia were selected.According to different doses of simvastatin drug,they were divided into two groups.The control group was given 20 mg/dsimvastatin treatment.The observation group was given 40 mg/d simvastatin treatment.The treatment effects of two groups wereobserved.The blood lipid indexes of two groups were compared.Results:The treatment total effective rates and adverse reactionswere compared between the observation group and the control group,and the differences were statistically significant(P<0.05).TheTC,TG and LDL-C indexes of the observation group were significantly lower than those of the control group(P<0.05).Conclusion:In the elderly patients with hypertension and hyperlipidemia,it is recommended to use the 40 mg/d dose of simvastatin fortreatment.It not only can improve the patient's blood lipid,and has less adverse reactions.