甘草酸二胺联合恩替卡韦治疗乙型肝炎肝硬化疗效观察

Curative effect observation of diammonium glycyrrhizinate combined with entecavir in the treatment of hepatitis b cirrhosis

目的:探讨甘草酸二胺联合恩替卡韦治疗乙型肝炎肝硬化的疗效。方法:收治乙型肝炎肝硬化患者61例,随机分为治疗组和对照组。对照组给予恩替卡韦治疗,治疗组给予恩替卡韦联合甘草酸二胺治疗,比较两组临床疗效。结果:治疗组ALT、AST、TBi L水平低于对照组,差异具有统计学意义(P<0.01)。两组HBV DNA阴转比较,差异无统计学意义(P>0.05)。两组治疗后HBV DNA水平明显下降,差异具有统计学意义(P<0.01)。结论:甘草酸二胺联合恩替卡韦治疗乙型肝炎肝硬化疗效较好,安全性好。

Objective:To evaluate the clinical curative effect observation of diammonium glycyrrhizinate combined with entecavirin the treatment of hepatitis b cirrhosis.Methods:61 cases of patients with hepatitis b cirrhosis were divided into the treatmentgroup and the control group randomly.The control group was treated with entecavir,the treatment group was treated with entecavircombined with diammonium glycyrrhizinate,the clinical curative effect of the two groups was compared.Results:The levels of ALT,AST and TBiL in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.01).There was no significant difference of HBV DNA negative conversion between the two groups(P>0.05).The HBV DNAlevels in the two groups after treatment were significantly decreased,the differences were statistically significant(P<0.01).Conclusion:Diammonium glycyrrhizinate combined with entecavir in the treatment of hepatitis b cirrhosis had better clinicalcurative effect and good safety.