肝功能正常的HBeAg阳性慢性乙型肝炎患者血清、肝组织HBVDNA与肝组织病理改变的关系

Relationship between serum,liver tissue HBV DNA and pathological changes in liver tissues of HBeAg positive patients with chronic hepatitis B and normal hepatic function

目的：探讨肝功能正常的HBeAg阳性慢性乙型肝炎病毒感染者血清中HBVDNA和肝组织中HBVDNA及肝组织病理改变的关系。方法：收治肝功能正常的HBeAg阳性慢性乙型肝炎病毒感染患者30例，行肝功能、血清HBVDNA、肝组织HBVDNA检测、肝组织病理检查及乙肝血清学标志物检测。结果：肝组织HBVDNA定量平均值4.16×106IU/mL，血清HBVDNA定量3.52×105IU/mL，肝组织HBVDNA定量与血清HBVDNA定量呈正相关(P＜0.05)。结论：血清HBVDNA定量与肝组织HBVDNA定量呈高度相关性，在一定程度上可代替检测肝组织中HBVDNA并判断病毒复制情况。

Objective:To investigate the relationship between serum HBV DNA,liver tissue HBV DNA and pathological changes in liver tissues of HBeAg positive patients with chronic hepatitis B and normal hepatic function.Methods:The hepatic function,serum HBV DNA,liver tissue HBV DNA and liver tissue pathological changes and hepatitis B serum markers of 30 cases of HBeAg positive patients with chronic hepatitis B virus infection and normal hepatic function were detected.Results:The average value of HBV DNA in liver tissue was 4.16×106 IU/mL,the value of serum HBV DNA was 3.52×105 IU/mL,and the value of HBV DNA in liver tissue was positively correlated with the value of serum HBV DNA(P<0.05).Conclusion:The value of serum HBV DNA was highly correlated with the value of HBV DNA in liver tissue,which could replace the HBV DNA in liver tissues and determine the virus replication in a certain extent.