抗结核药物治疗老年肺结核的不良反应及影响因素

Adverse effects of anti TB drugs in the treatment of elderly patients with pulmonary tuberculosis and its influencing factors

目的:探讨抗结核药物治疗老年肺结核的不良反应和影响因素。方法:收治老年肺结核患者400例,采用抗结核药物治疗,采用单因素和多因素Logistic回归分析对影响疾病的相关因素进行分析。结果:在400例患者中,118例(29.5%)发生药物不良反应。单因素分析表明,年龄、体重指数、肝病史、治疗类型、诊断类型是影响药物发生不良反应的因素,多因素Logistic回归分析表明,年龄和肝病史是影响药物发生不良反应的危险因素。结论:使用抗结核药物治疗老年肺结核,其药物不良反应发生率较高,高龄和有肝病史是影响药物发生不良反应的危险因素,临床应对患者的病史做好充分调查,降低不良反应发生率。

Objective:To explore the adverse effects of anti TB drugs in the treatment of elderly patients with pulmonary tuberculosis and its influencing factors.Methods:400 cases of elderly patients with pulmonary tuberculosis were selected.They were treated with anti tuberculosis drugs.We analyzed the influencing factors using single factor and multiple factors Logistic regression analysis.Results:In 400 patients,adverse drug reactions occurred in 118 cases(29.5%).Single factor analysis showed that age,body mass index,history of liver disease,treatment type and type of diagnosis were the factors that influence the adverse drug reaction.Multivariate Logistic regression analysis showed that age and history of liver disease were the risk factors of adverse drug reaction.Conclusion:Anti TB drugs were used in the treatment of elderly patients with pulmonary tuberculosis,and the incidence of adverse drug reactions was higher.Old age and history of liver disease were the risk factors of adverse drug reactions.In clinical work,we should fully investigate the patient’s medical history and reduce the incidence of adverse reactions.