早期帕金森病的磁共振扩散张量成像及波谱研究

Study on the magnetic resonance diffusion tensor imaging and spectrum of early Parkinson's disease

目的:分析磁共振扩散张量成像及波普对早期帕金森病诊断的作用。方法:收治帕金森病患者50例,其中早期患者25例、中晚期患者25例,选取非帕金森患者25例作为对照组,对患者同时进行弥散张量成像(DTI)和磁共振波谱(MRS)。结果:双侧基底核区FA值从对照组、早期组到中晚期组呈下降趋势:双侧丘脑区和双侧额叶区FA值从对照组、中晚期组到早期组呈下降趋势。NAA/Cr和Cho/Cr值从对照组、早期组到中晚期组呈下降趋势(P<0.05)。结论:DTI和MRS作为无创性检测方法可以为早期帕金森病的诊断提供理论依据,为疾病的早期诊断提供可靠依据。

Objective:To analyze the effect of magnetic resonance diffusion tensor imaging and spectrum in the diagnosis of early Parkinson’s disease.Methods:50 patients with Parkinson’s disease were selected,among which 25 cases were early patients,25 cases were middle-late patients.25 patients without Parkinson’s disease were selected as the control group.The patients were given diffusion tensor imaging(DTI) and nuclear magnetic resonance spectrum(MRS).Results:The bilateral basal ganglia FA values from the control group,the early group and the middle-late group showed a downward trend.The FA values of bilateral thalamus and bilateral frontal lobe from the control group,the middle-late group and the early group showed a downward trend. NAA/Cr and Cho/Cr values from the control group,the early group and the middle-late group showed a downward trend(P < 0.05).Conclusion:DTI and MRS as a noninvasive detection method can provide a theoretical basis for the diagnosis of early Parkinson's disease,and provide a reliable basis for the early diagnosis of disease.