终末期肾脏病患者应用头孢他啶后并发抗生素脑病的相关性分析

Correlation analysis of concurrent antibiotics encephalopathy of patients with end-stage renal disease after the application of ceftazidime

目的:分析终末期肾脏病患者应用头孢他啶后并发抗生素脑病的相关因素。方法:对86例终末期肾脏病患者给予头孢他啶治疗,将并发抗生素脑病的21例作为观察组,另外65例患者作为对照组,对比两组的有关资料,分析并发抗生素脑病的相关危险因素。结果:观察组的年龄、头孢他啶服用时间以及头孢他啶累计用量均多于对照组,差异有统计学意义(P<0.05);患者年龄、头孢他啶使用时间、ALb水平以及头孢他啶累计剂量均是导致抗生素脑病并发的危险因素(P<0.05)。结论:终末期肾脏病患者的年龄、头孢他啶使用时间、ALb水平以及头孢他啶累计剂量,均是导致抗生素脑病并发的危险因素。

Objective:To analyze the correlative factors of concurrent antibiotics encephalopathy of patients with end-stage renaldisease after the application of ceftazidime.Methods:86 patients with end-stage renal disease were given ceftazidime treatment.21cases were concurrent antibiotics encephalopathy as the observation group.Other 65 cases were as the control group.The relevantdata of two groups were compared.The related risk factors of concurrent antibiotics encephalopathy were analyzed.Results:The age,ceftazidime taking time and ceftazidime cumulative dosage of the observation group were significantly more than those of thecontrol group,and the differences were statistically significant(P<0.05).The age,ceftazidime taking time,ALb level andceftazidime cumulative dosage of patients were the risk factors for antibiotics encephalopathy concurrency(P<0.05).Conclusion:The age,ceftazidime taking time, ALb level and ceftazidime cumulative dosage of patients with end-stage renal disease are therisk factors for antibiotics encephalopathy concurrency.