膦甲酸钠与干扰素治疗带状疱疹的临床观察

Clinical observation of foscarnet sodium and interferon on the treatment of herpes zoster

目的:探讨膦甲酸钠和干扰素治疗带状疱疹的临床效果。方法:收治带状疱疹患者90例,随机分为治疗组和对照组,分别给予膦甲酸钠和干扰素治疗,比较两组治疗效果。结果:治疗组有效率95.6%,明显高于对照组的80.0%(P<0.05)。治疗后,治疗组疼痛计分显著低于对照组(P<0.05),较治疗前显著下降(P<0.05)。治疗后,治疗组的CD4+细胞数目和IL-2含量显著高于治疗前(P<0.05),组间比较,差异有统计学意义(P<0.05)。治疗后,治疗组躯体活动、精力、睡眠、社会生活和精神反应计分均高于对照组(P<0.05)。结论:与干扰素相比,膦甲酸钠治疗带状疱疹的临床效果更优。

Objective:To explore the clinical effect of foscarnet sodium and interferon on the treatment of herpes zoster.Methods:90 patients with herpes zoster were selected.They were randomly divided into the treatment group and the control group.They weretreated with foscarnet sodium and interferon respectively.We compared the treatment effect of the two groups.Results:The effectiverate of the treatment group of 95.6% was significantly higher than 80.0% in the control group(P<0.05).After treatment,the painscore of treatment group was significantly lower than the control group(P<0.05),and it was significantly lower than beforetreatment(P<0.05).After treatment,the number of CD4 + cells and the content of IL-2 in the treatment group were significantlyhigher than those before treatment(P<0.05),and the difference between groups was statistically significant(P<0.05).Aftertreatment,physical activity,energy,sleep,social life and mental reaction scores of the treatment group were higher than those in thecontrol group(P<0.05).Conclusion:Compared with interferon,the clinical effect of sodium benzoate in the treatment of herpeszoster was better.