盐酸帕罗西汀联合甜梦胶囊治疗脑卒中后抑郁疗效观察

Observation on the curative effect of paroxetine hydrochloride combined with sweet dream capsule in treatment of post stroke depression

目的:探讨帕罗西汀联合甜梦胶囊治疗脑卒中后抑郁的疗效。方法:对照组主要给予对症治疗,对治疗组给予帕罗西汀同时辅助甜梦胶囊治疗。治疗前、治疗后第4、8及12周末分别评定其疗效和不良反应。结果:治疗组治疗后4、8、12周HAMD、NIHSS评分明显低于对照组(P<0.01);治疗组的临床疗效明显优于对照组(P<0.01)。帕罗西汀联合甜梦胶囊组在治疗过程中无不良反应。结论:帕罗西汀联合甜梦胶囊治疗卒中后抑郁,疗效满意。

Objective:To investigate the curative effect of paroxetine combined with sweet dream capsule in treatment of poststroke depression.Methods:The control group was given symptomatic treatment.The treatment group was treated with paroxetinehydrochloride combined with sweet dream capsule at the same time.The efficacy and adverse reactions were evaluated at fourth,eighth and twelfth week after treatment respectively.Results:The HAMD and NIHSS scores of the treatment group weresignificantly lower than those in the control group at fourth week,eighth week,twelfth week after treatment(P<0.01).The clinicalefficacy of the treatment group was significantly better than that of the control group(P<0.01).Patients in the paroxetinehydrochloride combined with sweet dream capsule group had no adverse reactions during the treatment.Conclusion:Paroxetinehydrochloride combined with sweet dream capsule in the treatment of post stroke depression achieved satisfactory curative effect.