联合检测降钙素原和超敏C-反应蛋白在细菌性肺炎评估中的意义

Significance of combined detection of calcitonin and high sensitive C-reactive protein in the evaluation of bacterial pneumonia

目的:探讨降钙素原(PCT)与超敏C反应蛋白(hs-CRP)联合检测在细菌性肺炎病情评估中的临床意义。方法:收治细菌性肺炎患者45例为观察组,选择健康体检者40例为对照组,分别测定血清PCT与hs-CRP浓度。结果:治疗前,观察组血清PCT与hs-CRP浓度均显著高于对照组(P<0.05);治疗后,观察组PCT与hs-CRP浓度显著低于治疗前(P<0.05),但与对照组比较,差异无统计学意义(P>0.05)。观察组PCT与hs-CRP浓度呈正相关(r=0.847,P<0.01)。结论:细菌性肺炎患者血清PCT与hs-CRP浓度明显上升,治疗后PCT与hs-CRP浓度显著下降,有利于了解病情严重性,为随时评估治疗效果提供参考。

Objective:To explore the significance of combined detection of calcitonin and high sensitive C-reactive protein in theevaluation of bacterial pneumonia.Methods:45 patients with bacterial pneumonia were selected as the observation group.40healthy subjects were selected as the control group,we separately measured serum PCT and hs-CRP concentration.Results:Beforetreatment,the serum levels of PCT and hs-CRP in the observation group were significantly higher than those in the controlgroup(P<0.05).After treatment,the PCT and hs-CRP concentration in observation group was significantly lower than beforetreatment(P<0.05),but compared with the control group,the difference was not statistically significant(P>0.05).In theobservation group,PCT was positively correlated with the concentration of hs-CRP(r=0.847,P<0.01).Conclusion:In patients withbacterial pneumonia,serum PCT and hs-CRP concentrations were significantly increased.After treatment,the concentration ofPCT and hs-CRP were significantly decreased.They were helpful to understand the severity of the disease,and can providereference for evaluating the therapeutic effect at any time.