支气管舒张试验前后慢性阻塞性肺疾病患者肺功能的变化情况

Changes of pulmonary function of patients with chronic obstructive pulmonary disease before and after bronchial dilation test

目的:探讨慢性阻塞性肺疾病(COPD)患者在支气管舒张试验前后肺功能的变化情况。方法:收治COPD患者140例,其中Ⅰ级24例,Ⅱ级64例,Ⅲ级45例,Ⅳ级7例。比较支气管舒张试验前后不同分级的1 s用力呼气容积(FEV_1)、用力肺活量(FVC)、FEV_1%、6 s用力呼气容积(FEV6)、FEV_1/FVC及FEV_1/FEV_6的数值,分析FEV_6与FVC,FEV_1/FEV_6与FEV_1/FVC之间的相关性。结果:吸药后,所有患者的FEV_1、FEV_6、FEV_1%、FVC、FEV_1/FEV_6、FEV_1/FVC均有所升高。在支气管舒张试验前后,不同分级的FEV_1、FEV_6、FEV_1%、FVC比较,差异均有统计学意义(P<0.05)。FEV_1/FEV_6、FEV_1/FVC在Ⅱ级、Ⅲ级支气管舒张试验前后比较差异有统计学意义(P<0.05)。FEV_6与FVC,FEV_1/FEV_6与FEV_1/FVC存在相关性。结论:FEV_1、FEV_1%、FVC、FEV_6均可作为COPD患者支气管舒张试验后改善状况的指标,尤其以FEV_1、FEV_1%优势明显。FEV_6及FEV_1/FEV_6有可能取代FVC及FEV_1/FVC用于COPD患者的诊断。

Objective:To explore the changes of pulmonary function of patients with chronic obstructive pulmonary disease(COPD) before and after bronchial dilation test.Methods:140 patients with COPD were selected,in which 24 cases of Ⅰ grade,64 cases of Ⅱ grade,45 cases of Ⅲ grade,7 cases of Ⅳ grade.Before and after bronchial dilation test,1 s forced expiratory volume(FEV1),forced vital capacity(FVC),FEV1%,6 s forced expiratory volume(FEV6),FEV1/FVC and FEV1/FEV6 of different classificationswere compared.The correlation between FEV6 and FVC,FEV1/FEV6 and FEV1/FVC were analyzed.Results:After drug absorption,FEV1,FEV6,FEV1% ,FVC,FEV1/FEV6,FEV1/FVC of all patients were elevated.Before and after bronchial dilation test,FEV1,FEV6,FEV1% ,FVC of different classifications were compared,and the differences were statistically significant(P<0.05).FEV1/FEV6,FEV1/FVC of Ⅱ grade,Ⅲ grade before and after bronchial dilation test were compared,and the difference was statisticallysignificant(P<0.05).FEV6 and FVC,FEV1/FEV6 and FEV1/FVC had correlation.Conclusion:FEV1、FEV1%、FVC、FEV6can be as the improve performance indicators of COPD patients after bronchial dilation test,particularly FEV1, FEV1% advantagedobviously.FEV6 and FEV1/FEV6 may be used to replace FVC and FEV1/FVC for the diagnosis of COPD patients.