机械通气联合肺表面活性物质治疗重症新生儿呼吸窘迫综合征临床分析

Clinical analysis of the mechanical ventilation combined with pulmonary surfactant in the treatment of severe neonatal respiratory distress syndrome

目的:探讨机械通气联合肺表面活性物质治疗重症新生儿呼吸窘迫综合征的效果。方法:收治重症呼吸窘迫综合征新生儿70例,将其随机分为对照组和观察组各35例,对照组采用机械通气治疗,观察组采用机械通气联合肺表面活性物质治疗。结果:观察组治疗有效率高于对照组(P<0.05);两组患者的Pa O2水平均较治疗前显著提高,Pa CO2水平均较治疗前显著降低(P<0.05);在治疗后,与对照组相比,观察组的Pa O2水平显著升高,Pa CO2水平显著降低(P<0.05)。结论:机械通气联合肺表面活性物质治疗重症新生儿呼吸窘迫综合征具有良好效果。

Objective:To investigate the effects of mechanical ventilation combined with pulmonary surfactant in the treatment ofsevere neonatal respiratory distress syndrome.Methods:70 cases of severe respiratory distress syndrome neonates were selected.They were randomly divided into the control group and the observation group with 35 cases in each.Patients in the control grouptreated with mechanical ventilation,and patients in the observation group treated with mechanical ventilation combined withpulmonary surfactant.Results:The effective rate of the observation group was higher than that of the control group(P<0.05);thePaO2 levels of the two groups patients were significantly increased compared with the treatment before,and the PaCO2 levels weredecreased significantly compared with the treatment before(P<0.05);after the treatment,compared with the control group,the levelof PaO2 in the observation group was significantly higher,and the level of PaCO2 was significantly lower(P<0.05).Conclusion:Mechanical ventilation combined with pulmonary surfactant in the treatment of severe neonatal respiratory distress syndrome hasa good effect.