地西泮联合心理干预治疗酒精依赖伴抑郁症的临床疗效观察

Observation on the clinical effect of diazepam combined with psychological intervention in the treatment of alcohol dependence with depression

目的:探讨地西泮联合心理干预治疗酒精依赖伴抑郁障碍的临床疗效。方法:收治酒精依赖伴抑郁症患者68例,平分为两组,治疗组给予口服地西泮联合心理干预治疗,对照组给予单纯口服地西泮,分别于治疗前后采用HAMD-17和HAMA量表评定临床疗效及不良反应。结果:治疗组总有效率明显优于对照组(P=0.023)。治疗组治疗后HAMD和HAMA评分均较治疗前明显下降。结论:地西泮联合心理干预治疗酒精依赖伴抑郁障碍疗效优于单用地西泮,安全性高。

Objective:To explore the clinical effect of diazepam combined with psychological intervention in the treatment of alcohol dependence with depression.Methods:68 patients with alcohol dependence combined with depression were selectd.They were divided into the two groups on average.Patients in the treatment group received oral diazepam combined with psychological intervention,while patients in the control group were treated with oral diazepam,the clinical efficacy and adverse reactions were assessed by HAMD-17 and HAMA scale before and after treatment respectively.Results:The total effective rate of the treatment group was significantly better than that of the control group(P=0.023).After treatment,the HAMD and HAMA scores of the treatment group were significantly decreased compared with those before the treatment.Conclusion:The effect of diazepam combined with psychological intervention in the treatment of alcohol dependence with depression is better than that of only use diazepam,and the safety is high.