不同剂量的坦索罗辛在输尿管下段结石中的疗效比较

Curative effect comparison of different doses of tamsulosin in distal ureteral calculus

目的:比较不同剂量的坦索罗辛在治疗输尿管下段结石中的效果。方法:将60例输尿管下段结石患者随机分为两组。组Ⅰ给予坦索罗辛0.2 mg,1次/d;组Ⅱ给予坦索罗辛0.4 mg,1次/d;观察随访2周。结果:组Ⅰ和组Ⅱ结石完全排出率分别为57%和80%,两组比较,差异无统计学意义(P=0.052);组Ⅰ和组Ⅱ平均排石时间分别为(7.2±2.6)d和(5.5±2.3)d,两组比较,差异有统计学意义(P<0.05);2周内因发生肾绞痛而需镇痛治疗,分别为11例(37%)和4例(13%),两组比较,差异有统计学意义(P<0.05);2周内两组均未出现明显不良反应。结论:坦索罗辛能有效促进输尿管下段结石排出,缩短排石时间,并减少排石过程中肾绞痛的发生;在缩短结石排出时间、降低肾绞痛发生率上,用坦索罗辛0.4mg/d明显优于用坦索罗辛0.2mg/d。

Objective:To compare the curative effect of different doses of tamsulosin in the treatment of distal ureteral calculus.Methods:60 patients with distal ureteral calculus were randomly divided into two groups.The group Ⅰ was given tamsulosin 0.2 mg,1 time 1 day.The group Ⅱ was given tamsulosin 0.4 mg,1 time 1 day.They were observed and followed up for 2 weeks.Results:The calculus complete removal rate of the group Ⅰ and the group Ⅱ were respectively 57% and 80%,there was no significant difference between the two groups(P=0.052).The average removing urinary calculus time of the group Ⅰ and the group Ⅱ were respectively (7.2±2.6)days and (5.5±2.3)days,there was significant difference between the two groups(P<0.05).11 cases(37%) and 4 cases(13%) occured renal colic and need analgesia treatment in 2 weeks,there was significant difference between the two groups(P<0.05).No obvious adverse reactions occurred in the two groups in 2 weeks.Conclusion:Tamsulosin can effectively promote the removal of distal ureteral calculus,shorten the removing urinary calculus time,and reduce the incidence of renal colic in the process of removing urinary calculus.In shortening the removing urinary calculus time,reducing the incidence of renal colic,using tamsulosin 0.4 mg one day is significantly better than that of tamsulosin 0.2 mg one day.