干预高同型半胱氨酸血症150例的临床方法研究

Clinical method research of intervention for high homocysteine in 150 cases

目的:探讨不同方案长期干预高同型半胱氨酸(Hcy)血症的临床相关性。方法:收治高Hcy血症患者150例,随机分为3组,各50例。A组每日口服叶酸0.2 mg、维生素B62.5 mg、维生素B12100μg;B组每日口服叶酸5 mg、维生素B630 mg、维生素B121.5 mg;C组每日口服叶酸15 mg,比较3组的治疗效果。结果:用药后,各组Hcy水平均显著下降,组间差异无统计学意义(P>0.05)。治疗过程中,A组1例因头晕皮疹停药,B组9例因多种不良反应停药,C组17例因多种不良反应停药。结论:3组均能显著降低血浆Hcy水平,临床相关性:A组明显优于B组、C组,B组优于C组。

Objective:To explore the clinical relevance of different schemes for long term intervention of high homocysteine.Methods:150 patients with high homocysteine were selected.They were randomly divided into 3 groups with 50 patients in each.A group was treated with daily oral folic acid 0.2 mg,vitamin B6 2.5 mg,vitamin B12 100 μg;B group was treated with daily oral folic acid 5 mg,vitamin B6 30 mg,vitamin B12 1.5 mg;C group was treated with daily oral folic acid 15 mg;then we compared the treatment effect of the 3 groups.Results:After treatment,the levels of Hcy in all groups were significantly decreased,there was no significant difference between groups(P>0.05).In the course of treatment,1 case in A group was forced to stop the drug for dizzy and rash; 9 cases in B group were forced to stop the drug for adverse reaction;17 cases in C group were forced to stop the drug for adverse reaction.Conclusion:Plasma Hcy levels in three groups were significantly lower.The A group was significantly better than that in B group and C group,and B group was better than C group.