氟哌啶醇治疗谵妄100例临床研究

Clinical study of haloperidol in the treatment of delirium in 100 cases

目的:探讨氟哌啶醇治疗谵妄的临床疗效及安全性。方法:收治谵妄状态患者100例,随机分为对照组和氟哌啶醇组各50例。对照组只针对谵妄的病因进行保守治疗;氟哌啶醇组在对照组基础上给予肌内注射予氟哌啶醇治疗。用总评量表疾病严重程度(CGI-SI)和简明精神病量表(BPRS)2个指标评价两组疗效,同时观察不良反应发生情况。结果:氟哌啶醇组显效率明显高于对照组(P<0.05);两组间BRPS评分和CGI-SI评分比较,差异均有统计学意义(P<0.05);氟哌啶醇组患者出现相关不良反应,但可耐受。结论:氟哌啶醇治疗谵妄安全、有效。

Objective:To explore the clinical curative effect and security of haloperidol in the treatment of delirium.Methods:100patients with delirium were selected.They were randomly divided into the control group and the haloperidol group with 50 cases ineach. The control group were only given the conservative treatment aimed at the cause of delirium.Haloperidol group were givenhaloperidol intramuscular injection treatment based on the control group.The curative effect of two groups was evaluated byoverall rating scale disease severity(CGI-SI) and Brief Psychiatric Rating Scale(BPRS) 2 indexes.The occurrence of adversereactions was observed at the same time.Results:The obvious effective rate of the haloperidol group was significantly higher thanthat of the control group(P<0.05).The BRPS scores and CGI-SI scores were compared between groups,and the differences werestatistically significant(P<0.05).The patients in the haloperidol group appeared related adverse reactions,but they could tolerate.Conclusion:The haloperidol in the treatment of delirium is safe and effective.