两种用药方案治疗幽门螺杆菌相关性十二指肠溃疡的疗效对比

Curative effect comparison of two drug regimens in the treatment of helicobacter pylori associated duodenal ulcer

目的:分析两种用药方案治疗幽门螺杆菌相关性十二指肠溃疡的临床疗效。方法:收治幽门螺杆菌相关性十二指肠溃疡患者154例,随机分为对照组和研究组各77例。对照组给予克拉霉素、阿莫西林、埃索美拉唑进行治疗;研究组给予呋喃唑酮、阿莫西林、埃索美拉唑进行治疗。比较两组患者的疗效。结果:研究组总有效率96.10%(74/77),对照组94.81%(73/77),差异无统计学意义(P>0.05)。研究组幽门螺杆菌根除率92.21%(71/77),对照组93.51%(72/77),差异无统计学意义(P>0.05)。研究组不良反应发生率6.49%(5/77),对照组6.49%(5/77),差异无统计学意义(P>0.05)。结论:两种用药方案治疗幽门螺杆菌相关性十二指肠溃疡的疗效相当,疗效理想,幽门螺杆菌的根除率较高,安全性良好。

Objective:To analyze the clinical curative effect of two drug regimens in the treatment of helicobacter pylori associated duodenal ulcer.Methods:154 patients with helicobacter pylori associated duodenal ulcer were selected.They were randomly divided into the control group and the study group with 77 cases in each.The control group was given clarithromycin,amoxicillin and esomeprazole treatment.The study group was given furazolidone,amoxicillin and esomeprazole treatment.The curative effects of two groups were compared.Results:The total effective rate of the study group was 96.10% (74/77);the control group was 94.81%(73/77);the difference was not statistically significant(P>0.05).The eradication rate of helicobacter pylori in the study group was 92.21%(71/77);the control group was 93.51%(72/77);the difference was not statistically significant(P>0.05).The incidence rate of adverse reactions in the study group was 6.49%(5/77);the control group was 6.49%(5/77);the difference was not statistically significant(P>0.05).Conclusion:The curative effects of two drug regimens in the treatment of helicobacter pylori associated duodenal ulcer are equivalent,and the curative effect is ideal.The eradication rate of helicobacter pylori is high,and the safety is good.