单磷酸阿糖腺苷联合干扰素α-1b治疗110例小儿手足口病疗效观察

Curative effect observation of adenine arabinoside monophosphate combined with interferon α-1b in the treatment of children with hand-foot-mouth disease in 110 cases

目的:探讨单磷酸阿糖腺苷联合干扰素α-1b治疗小儿手足口病的疗效。方法:将110例手足口病患儿随机分为观察组和对照组各55例,观察组给予单磷酸阿糖腺苷和干扰素α-1b治疗,对照组给予利巴韦林治疗,观察临床疗效。结果:观察组总有效率高于对照组,观察组退热时间、皮疹消退时间、治疗时间少于对照组(P<0.05)。结论:单磷酸阿糖腺苷联合干扰素α-1b雾化吸入治疗手足口病效果优于利巴韦林,疗效安全,无明显不良反应。

Objective:To explore the curative effect of adenine arabinoside monophosphate combined with interferon α-1b in the treatment of children with hand-foot-mouth disease.Methods:110 children with hand-foot-mouth disease were randomly divided into the observation group and the control group with 55 cases in each.The observation group was given adenine arabinoside monophosphate and interferon α-1b treatment.The control group was given ribavirin treatment.The clinical curative effect was observed.Results:The total effective rate of the observation group was higher than that of the control group,the cooling time,skin rash subsided time,treatment time of the observation group were less than those of the control group(P<0.05).Conclusion:The effect of adenine arabinoside monophosphate combined with interferon α-1b in the treatment of hand-foot-mouth disease is better than that of ribavirin,the curative effect is safety,there is no obvious adverse reactions.