质子泵抑制剂治疗胃食管反流病的临床观察

Clinical observation of proton pump inhibitor in the treatment of gastroesophageal reflux disease

目的:探究应用质子泵抑制剂治疗胃食管反流病的临床疗效。方法:收治胃食管反流病患者90例,随机平分为两组,观察组接受埃索美拉唑治疗,对照组接受雷贝拉唑治疗,比较两组疗效。结果:两组经治疗后,症状均有所改善。观察组总不良反应发生率26.67%,明显低于对照组的84.44%,差异有统计学意义(P<0.05)。结论:质子泵抑制剂治疗胃食管反流病临床疗效满意,且应用埃索美拉唑不良反应发生情况较少。

Objective:To explore the clinical effect of proton pump inhibitor in the treatment of gastroesophageal reflux disease.Methods:90 patients with gastroesophageal reflux disease were selected.Ty were randomly divided into the two groups.Pients inthe observation group received esomeprazole,while patients in the control group received rabeprazole.The clinical effect of twogroups was compared.Results:The symptoms were improved of patients after treatment in two groups.The total adverse reactionrate in the observation group of 26.67% was significantly lower than that in the control group of 84.44% ,and the differencebetween groups was statistically significant(P<0.05).Conclusion:The clinical effect of proton pump inhibitor in the treatment ofgastroesophageal reflux disease is satisfactory,and the application of esomeprazole has less adverse reactions.