肺表面活性物质治疗足月新生儿急性呼吸窘迫综合征的效果探析

The effect of pulmonary surfactant in the treatment of full-term neonatal acute respiratory distress syndrome

目的:探讨分析肺表面活性物质治疗足月新生儿急性呼吸窘迫综合征的临床疗效。方法:收治急性呼吸窘迫综合征的足月新生儿40例,随机分两组,各20例,对照组采用机械通气支持治疗,观察组在此基础上联合使用肺表面活性物质进行治疗,比较两组的临床疗效和治疗相关情况。结果:观察组的症状恢复时间、呼吸机使用时间以及重症监护病房治疗时间均明显短于对照组(P<0.05);对照组的恢复总有效率85%,低于观察组的95%(P<0.05);观察组并发气胸、肺出血以及呼吸机相关肺炎发生率和死亡率均明显低于对照组(P<0.05)。结论:肺表面活性物质治疗足月新生儿急性呼吸窘迫综合征具有很好的疗效,可明显提高患儿治愈的有效率。

Objective:To investigate the clinical curative effect of pulmonary surfactant in the treatment of neonatal acuterespiratory distress syndrome.Methods:40 children with acute respiratory distress syndrome were selected.They were randomlydivided into two groups,20 cases in each.The control group received the treatment of mechanical ventilation support.Theobservation group were given combination of pulmonary surfactant treatment on the basis the control group.Clinical curative effectand treatment between groups were compared.Results:The symptom recovery time,ventilator use time and intensive care unittreatment time were significantly shorter than those of the control group(P<0.05).The recovery of total effective rate of controlgroup was 85% lower than that of the observation group of 95% (P<0.05).The incidence and mortality of the patients withpneumothorax,pulmonary hemorrhage and respiratory associated pneumonia were significantly lower than those in the controlgroup(P<0.05).Conclusion:Pulmonary surfactant in the treatment of neonatal acute respiratory distress syndrome has goodcurative effect.It can significantly improve the cure efficiency.