丹参川芎嗪联合低分子肝素预防 下肢骨折术后深静脉血栓形成的临床疗效

Clinical effect of Salvia miltiorrhiza Ligustrazine Combined with low molecular weight heparin in prevention of deep vein thrombosis after lower limb fracture

目的:探讨丹参川芎嗪联合低分子肝素钙预防下肢骨折患者术后深静脉血栓(DVT)形成的应用效果。方法:收治下肢骨折患者96例,随机分两组,各48例,对照组术后常规应用低分子肝素钙注射液预防下肢深静脉血栓的形成,观察组在对照组基础上加用丹参川芎嗪注射液,比较两组患者术后深静脉血栓形成率及不良反应发生情况。结果:术后2周彩色多普勒超声检查结果显示,观察组术后发生下肢DVT 2例(4.17%),低于对照组的10例(20.83%),差异有统计学意义(P<0.05)。结论:下肢骨折手术术后应用丹参川芎嗪联合低分子肝素预防下肢深静脉血栓效果较为理想,下肢DVT形成率较低,并且应用较为安全。

Objective:To discuss the clinical effect of Salvia miltiorrhiza Ligustrazine combined with low molecular weight heparinin prevention of deep vein thrombosis after lower limb fracture.Methods:96 patients with fracture of lower limb were selected.They were randomly divided into two groups,each of 48 cases.The control group was treated with low molecular weight heparincalcium in the prevention of deep vein thrombosis of lower limbs.The observation group was added with Salvia Ligustrazine injectionon the basis of control group.Postoperative deep vein thrombosis rate and adverse reactions between groups were compared.Results:After two weeks,color Doppler ultrasound examination showed that the observation group with DVT of 2 cases(4.17%) waslower than that of the control group of 10 cases(20.83%) (P<0.05).Conclusion:Salvia Ligustrazine combined with low molecularweight heparin in the prevention of deep venous thrombosis of lower extremity after lower limb fracture surgery is more ideal.DVTformation rate of lower limb is lower,and the application is more safe.