氟哌噻吨美利曲辛辅助治疗伴有焦虑抑郁的难治性胃食管反流病100例的疗效观察

Curative effect observation of flupentixol and melitracen adjuvant therapy for refractory gastroesophageal reflux disease complicated with anxiety and depression in 100 cases

目的:探讨氟哌噻吨美利曲辛治疗伴焦虑抑郁难治性胃食管反流病的疗效。方法:收治伴焦虑抑郁难治性胃食管反流患者220例,分为观察组(n=100)和对照组(n=120),对照组给予埃索美拉唑治疗,观察组在对照组基础上加用氟哌噻吨美利曲辛治疗,比较两组的治疗效果。结果:观察组总有效率91.4%,明显高于对照组的78.6%(P<0.05)。结论:在常规抑酸治疗基础上加用氟哌噻吨美利曲辛治疗伴有焦虑抑郁症状的难治性胃食管反流患者,能调整患者负面情绪,显著改善患者的临床症状,疗效确切。

Objective:To explore the curative effect of flupentixol and melitracen adjuvant therapy for refractory gastroesophagealreflux disease complicated with anxiety and depression.Methods:220 patients with refractory gastroesophageal reflux diseasecomplicated with anxiety and depression were selected.They were divided into the observation group(n=100) and the controlgroup(n=120).The patients in the control group were given esomeprazole treatment.The patients in the observation group addedflupentixol and melitracen on the basis of the control group.We compared the treatment effect of two groups.Results:In theobservation group,the total effective rate of 91.4% was significantly higher than 78.6% of the control group(P<0.05).Conclusion:On the basis of conventional acid suppression therapy,application of flupentixol and melitracen adjuvant therapy for refractorygastroesophageal reflux disease complicated with anxiety and depression can adjust the negative emotions of patients,andsignificantly improve the clinical symptoms.Curative effect was exact.