小儿复方地芬诺酯中毒50例临床分析

Clinical analysis of 50 cases of pediatric compound diphenoxylate poisoning

目的:分析小儿复方地芬诺酯中毒的救治与预防。方法:对50例患儿的临床表现、诊断、辅助检查及化验资料、治疗进行回顾性分析。结果:48例患儿均抢救成功。2例患儿由于病史不清,未彻底反复洗胃、导泻,头颅CT显示严重脑水肿,出现失明、智力障碍,生活不能自理。脑电图提示慢波。纳洛酮治疗效果满意,但仍有严重病例出现。结论:早期诊断、及时彻底反复洗胃、导泻及应用纳洛酮治疗是抢救复方地芬诺酯中毒成功的关键。

Objective:To analyze the treatment and prevention of pediatric compound diphenoxylate poisoning.Methods:Theclinical manifestations,diagnosis,auxiliary examination,laboratory data and treatment of 50 cases of children were analyzedretrospectively.Results:48 cases were rescued successfully.Because the history was not clear,2 cases were given not thoroughlyrepeated gastric lavage and catharsis;the head CT displayed severe cerebral edema;they appeared blindness,mental retardationand life cannot provide for themself.The electroencephalogram slowed slow wave.The naloxone treatment effect was satisfactory,but there were still serious cases.Conclusion:Early diagnosis,timely and thorough repeated gastric lavage,catharsis and applicationof naloxone treatment are the keys to rescue compound diphenoxylate poisoning successfully.