急性期克罗恩病患者结肠黏膜IL-4及IL-17的表达

Expression of IL-4 and IL-17 in colonic mucosa of patients with Crohn's disease in acute stage

目的:探讨急性期克罗恩病患者结肠黏膜IL-4、IL-17炎性因子的表达水平及意义。方法:收治急性期克罗恩病患者32例,选择健康人30例为对照组,检测IL-4、IL-17的m RNA在各组患者结肠黏膜组织中的表达水平。结果:急性期克罗恩病患者结肠黏膜IL-17、IL-4的表达水平明显高于对照组(P<0.01);随疾病程度加重,IL-17、IL-4的表达水平越高(P<0.05)。结论:结肠黏膜因子IL-17、IL-4的表达可能分别参与了急性期克罗恩病黏膜的损伤和修复过程;结肠黏膜因子IL-17、IL-4的表达水平与黏膜损伤的程度呈正相关。

Objective:To explore the level of expression and significance of IL-4 and IL-17 in colonic mucosa of patients withCrohn's disease in acute stage.Methods:32 patients with acute Crohn's disease were selected,and 30 cases of healthy people wereselected as the control group.We examined the expression levels of IL-4,IL-17 mRNA in colonic mucosa of the two groups.Results:The expression level of IL-4 and IL-17 in colonic mucosa of patients with Crohn's disease in acute stage was significantlyhigher than that of the control group(P<0.01).The expression level of IL-4 and IL-17 was higher with the increase of severity ofthe disease(P<0.05).Conclusion:The expression of IL-4 and IL-17 may be involved in the damage and repair process of themucosa of Crohn's disease in acute stage.The expression levels of IL-4 and IL-17 were positively correlated with the degree ofmucosal injury.