两种浓度5-氨基酮戊酸光动力疗法治疗中重度痤疮疗效观察

A study on clinical efficacy of two kinds of concentration of 5-Aminolevulinic acid photodynamic therapy in treatment of moderate to severe acne

目的:探讨两种浓度5-氨基酮戊酸光动力疗法(ALA-PDT)治疗中重度痤疮的有效性及安全性。方法:将68例中重度痤疮患者随机分为两组:低浓度组:31例,给予5%ALA-PDT治疗;高浓度组:37例,给予10%ALA-PDT治疗,两组均每2周治疗1次,共治疗3次。在治疗后第2、4、6周对两组患者进行疗效判断和比较,同时记录治疗过程中出现的不良反应。结果:31例接受5%ALA-PDT治疗的患者经3次治疗后,总有效率87.10%;37例接受10%ALA-PDT治疗的患者经3次治疗后,总有效率为94.59%,两组疗效相比无统计学意义(P>0.05)。结论:5%ALA封包组与10%ALA封包组疗效相比无统计学意义,但低浓度组红斑、水肿、色素沉着等不良反应小。

Objective To study the safety and efficacy of two kinds of concentrations of 5-aminolevulinic acid photodynamictherapy (5-ALA-PDT) in the treatment of moderate to severe acne. Methods 68 patients with moderate to severe acne wererandomly divided into two groups: 31 cases in low concentration group were treated with 5% 5-ALA followed by red laserirradiation with a photodynamic therapy device; 37 patients in high concentration group were treated with 10% 5-ALA followedby red laser irradiation with a photodynamic therapy device. Patients in both groups were treated once every two weeks, 3times totally. The patients were followed up 2, 4, and 6 weeks after the treatment, the therapeutic effects in two groups werecompared and the adverse reactions were recorded. Results After 3 times treatments, the total effective rates of low and highconcentration groups were respectively 87.1% and 94.59%. There was no significant difference between the two groups (P >0.05).Conclusion The clinical efficacy has no significant difference between 5% 5-ALA group and 10% 5-ALA group, but the caseswith adverse reactions in 5% 5-ALA group, such as erythema, oedema, hyperpigmentation, were less.