右美托咪啶与咪达唑仑用于全身麻醉患者镇静效果分析

Analysis of the effect of dexmedetomidine and midazolam for sedation in patients with general anesthesia

目的:比较右美托咪啶与咪达唑仑用于全身麻醉患者镇静效果分析。方法:将80例患者随机平分成M组和N组,M组采用右美托咪啶镇静,N组采用咪达唑仑镇静,各时间段采用BIS监测、记录患者入室给右美托咪定及咪达唑仑前(T_0)、麻醉诱导(T_1)、气管插管即时(T_2)、手术结束(T_3)及拔出气管导管(T_4)时间段的HR、BP变化及拔管时间。结果:M组在T_1、T_2时间段BIS值明显低于N组T_1时间段BIS值,HR减慢较N组明显、BP变化降低,差异有统计学意义(P<0.05),M组拔管时间明显缩短,差异有统计学意义(P<0.05)。结论:右美托咪啶用于全身麻醉镇静效果满意,血流动力学稳定,但麻醉诱导后心率会减慢。

Objective:To compare the effect of dexmedetomidine and midazolam for sedation in patients with general anesthesia.Methods:80 patients were randomly divided into the group M and the group N.The group M was treated with dexmedetomidine for sedation.Midazolam sedation was used in the group N,various time periods using BIS monitoring.We recorded the BP,HR changes and extubation time of T0 that patients entered the operating room before given dexmedetomidine and midazolam,T1 time of induction of anesthesia and tracheal intubation instant T2,operation end of T3 and T4 time of pulling out the tracheal catheter.Results:The BIS value of the group M in T1 and T2 time period was significantly lower than that of T1 time period BIS value of the group N,HR slowed down significantly compared with the group N,BP change decreased,and there were significant differences(P<0.05).The extubation time of the group M was significantly shorter,and there was a significant difference(P<0.05).Conclusion: Its hemodynamics is stable, but the heart rate slows down after anesthesia induction.Dexmedetomidine has a satisfactory sedative effect in the use of general anesthesia,and its hemodynamics is stable,but the heart rate will slow down after anesthesia induction.