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间质化与结直肠癌相关性的研究进展

Research progression of the relativity between epithelial-mesenchymal transition and colorectal cancer
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摘要 上皮间质化(epithelial-mesenchymal transition,EMT),指上皮细胞在某些特定因素下获得间质细胞表型的过程。在恶性肿瘤的发生和进展过程中EMT发挥重要作用。结直肠癌细胞的侵袭运动和肿瘤远处转移与EMT密切相关,EMT可能成为未来抑制结直肠癌转移的一个新的靶点,为肿瘤治疗开辟一个新方向。 Epithelial mesenchymal transition (EMT), refers to the epithelial cells obtainedinterstitial cell phenotype under some specific factors, EMT play an important role in the process of malignanttumor occurrence and progress. The invasion and distant metastasis of colorectal cancer cell is closely relatedto the EMT, EMT may become a new target for inhibiting metastasis of colorectal cancer, and be a new fieldfor tumor treatment.
作者 费强 封益飞 孙跃明 Fei Qiang;Feng Yifei;Sun Yueming(Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China)
机构地区 南京医科大学第一附属医院结直肠外科
出处 《中华结直肠疾病电子杂志》 2016年第1期64-67,共4页 Chinese Journal of Colorectal Diseases(Electronic Edition)
基金 教育部基金项目(2012YQ030261)
关键词 结直肠肿瘤 研究 进展 Colorectal neoplasms Research Progress
分类号 R735.34 [医药卫生—肿瘤]
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参考文献44

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中华结直肠疾病电子杂志
2016年 第1期

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