低KPS评分老年非霍奇金淋巴瘤综合治疗达CR一例报告及文献复习

A report on curative effect of CR of comprehensive treatment on non-Hodgkin lymphoma in the elderly with low KPS score and the literature review

目的:研究中医药治疗在低KPS评分老年非霍奇金淋巴瘤(NHL)各个阶段的合理应用及临床意义。方法:对1例经典CHOP方案6周期化疗配合中医药治疗KPS评分为50分老年NHL疗效达CR的全病程进行分析,并复习文献。结果:结合文献复习老年NHL的临床特点、治疗及CHOP方案与中医药治疗模式在临床中的具体应用:低KPS时以单纯中医药治疗为主,或减药(或减量)的CHOP方案化疗配合中医加载治疗;KPS评分高时时以CHOP方案化疗为主,同时配以中医防护治疗;疗效达CR后,采用中医巩固治疗模式。结论:老年NHL虽然KPS评分低,预后差,但在治疗过程中合理运用不同中医药治疗模式,疗效仍可达CR。

Objective: To study the application of the TCM medicine in treating non-Hodgkin lymphoma in the elderly (elderly NHL)with low KPS score at various stages and clinical significance. Methods: To report 1 case of curative effect of CR of classical CHOP planfor 6 cycles of chemotherapy with TCM treatment on elderly NHL with 50 points of KPS score and analyze the whole course of the disease,and review the literature. Results: Based on related literature, we review clinical characteristics and treatment of elderly NHL, and theclinical application of CHOP scheme and treatment mode of TCM: the patient with low KPS is given priority to pure TCM treatment, orby drugs (or dose) reduced scheme of CHOP chemotherapy with loads of TCM treatment; CHOP chemotherapy is given priority to the patientwith high KPS, at the same time, cooperating with the protection of TCM treatment; After the curative effect of CR, we can adopt themodel of consolidation treatment of TCM. Conclusion: Although elderly NHL patients’ KPS score and prognosis are poor, we use differenttreatment modes of TCM reasonably at various stages of this disease, the curative effect would be up to CR.