阿司匹林、氯吡格雷联合替罗非班强化抗栓在老年高龄非ST段抬高型急性冠脉综合征中的应用分析

Analysis of the application of aspirin,clopidogrel combined with tirofiban strengthen antithrombotic therapy in elderly patients with non ST segment elevation acute coronary syndrome

目的:探讨阿司匹林、氯吡格雷联合替罗非班强化抗栓治疗高龄非ST段抬高型急性冠脉综合征(NSTEACS)临床效果。方法:收治NSTEACS老年患者120例,随机平分为两组。对照组给予常规西医综合治疗,同时给予常规抗血小板聚集药物治疗。试验组给予阿司匹+氯吡格雷+替罗非班强化抗栓治疗。观察、比较两组临床总有效率、主要不良心脏事件发生率及不良反应情况。结果:试验组临床总有效率96.7%,显著高于对照组的76.7%(P<0.05)。试验组主要不良心脏事件发生率均显著低于对照组(P<0.05)。结论:运用阿司匹林、氯吡格雷联合替罗非班强化抗栓治疗高龄NSTEACS患者临床疗效确切,可显著降低不良心脏事件发生率,降低出血等不良反应发生率。

Objective:To analyze the clinical effect of the application of aspirin,clopidogrel combined with tirofiban strengthenantithrombotic therapy in the treatment of elderly patients with non ST segment elevation acute coronary syndrome(NSTEACS).Methods:120 elderly patients with NSTEACS were selected.They were randomly divided into the two groups.The control groupwas given routine western medicine comprehensive treatment,at the same time,the conventional anti platelet aggregation drugtherapy was also given to the patients.The experimental group was treated with aspirin,clopidogrel combined with tirofibanstrengthen antithrombotic therapy.The clinical total effective rate,the incidence of major adverse cardiac events and adversereactions were observed and compared between groups.Results:The clinical total effective rate of the experimental group was96.7% ,which higher than that of the control group of 76.7% (P<0.05).The incidence of major adverse cardiac events in theexperimental group was significantly lower than that in the control group(P<0.05).Conclusion:The clinical curative effect ofaspirin,clopidogrel combined with tirofiban strengthen antithrombotic therapy in elderly patients with NSTEACS is significant,which can significantly reduce the incidence of adverse cardiac events,reduce the incidence of bleeding and other adversereactions.