奥氮平治疗老年精神分裂症的疗效观察

To observe the efficacy of olanzapine in the treatment of elderly schizophrenia

目的分析奥氮平治疗老年精神分裂症临床效果。方法选取2015年1月～2016年1月期间收治的老年精神分裂症患者86例，按照双盲法随机分成两组，对照组43例，采用利培酮治疗；研究组43例，采用奥氮平治疗。对比两组患者的临床治疗效果和药物不良反应发生情况。结果研究组患者的临床治疗总有效率与对照组相近（P＞0.05）；研究组在锥体外系副反应以及转氨酶升高两方面的不良反应发生率低于对照组，差异具有统计学意义（P＜0.05）。结论利培酮和奥氮平在治疗老年精神分裂症上均疗效显著，但奥氮平安全性更好，更适宜老年精神分裂症患者的临床治疗。

Objective To analyze clinical effect of olanzapine in the treatment of elderly schizophrenia. Methods From January 2015 to January 2016,86 cases of elderly patients with schizophrenia were randomized into two groups, according to the double-blind methods. The control group, 43 cases of thepatients were treated by risperidone therapy, and the research group, 43 cases of patients were with olanzapine treatment. Comparison of two groups of patientswith clinical therapeutic effects and adverse drug reactions occurred. Results The total effective rate of were close of the two with no significant difference( P >0.05); But the side effects of the two had significant difference(P < 0.05), The incidence of adverse reactions was lower in the research group. conclusion therisperidone and olanzapine in the treatment of elderly schizophrenia curative effect is the same, but the olanzapine security is better.