咪达唑仑对重症医学科机械通气患者镇静效果研究

Effect of midazolam on sedation in patients with mechanical ventilation in intensive care unit

目的:探讨、研究咪达唑仑对重症医学科机械通气患者镇静的应用效果。方法:将重症医学科机械通气患者随机分成对照组和试验组,对照组给予丙泊酚,试验组给予咪达唑仑。结果:试验组用药1 h后HR、SpO_2、PIP、FiO_2、PaO_2等指标与对照组相比,差异无统计学意义(P>0.05);且试验组Ramsay镇静效果与对照组相比,差异也无统计学意义(P>0.05)。结论:在重症医学科机械通气患者中咪达唑仑和丙泊酚均能够达到镇静效果。

Objective:To investigate the effect of midazolam on sedation in patients with mechanical ventilation in intensive careunit.Methods:Patients with mechanical ventilation in intensive care unit were randomly divided into the control group and theexperimental group.The control group was treated with propofol.The experimental group was treated with midazolam.Results:TheHR,SpO2,Pip,FiO2,PaO2 of the patients 1h after the treatment between groups were compared,and the difference was notstatistically significant(P>0.05).There was no significant difference between the experimental group and the control group in thesedative effect of Ramsay(P>0.05).Conclusion:Both midazolam and propofol in patients with mechanical ventilation in theintensive care unit can achieve the sedative effect.