阿替普酶静脉溶栓治疗急性缺血性脑卒中的安全性和有效性分析

Safety and effectiveness of intravenous thrombolytic therapy with alteplase for patients with acute ischemic stroke

目的:探讨阿替普酶静脉溶栓治疗急性缺血性脑卒中的安全性和有效性。方法:收治急性缺血性脑卒中患者82例,分为两组。对照组给予常规治疗,观察组在对照组基础上给予阿替普酶静脉溶栓治疗,比较两组疗效和不良反应发生情况。结果:观察组溶栓后2 h、24 h、14 d、3个月NIHSS评分显著低于对照组,差异均有统计学意义(P<0.05)。观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论:阿替普酶静脉溶栓治疗急性缺血性脑卒中的疗效较好,不良反应发生率未增加。

Objective:To investigate the safety and effectiveness of intravenous thrombolytic therapy with alteplase for patientswith acute ischemic stroke.Methods:82 cases of patients with acute ischemic stroke were divided into two groups.The controlgroup was given conventional treatment.The observation group was given intravenous thrombolytic therapy with alteplase on thebasis of the control group.The curative effect and adverse reaction of the two groups were compared.Results:The NIHSS scores ofthe observation group 2 h, 24 h, 14 d, 3 months after thrombolytic therapy were significantly lower than those of the control group,and the differences were statistically significant (P<0.05).The total effective rate of the observation group was significantly higherthan that of the control group,and the difference was statistically significant (P<0.05).Conclusion:Intravenous thrombolytictherapy with alteplase for acute ischemic stroke had better curative effect and the incidence of adverse reactions was not increased.