血清降钙素原诊断弥漫性结缔组织病患者细菌感染的价值研究

The value of serum calcitonin in the diagnosis of bacterial infection in patients with diffuse connective tissue disease

目的:评估血浆降钙素原(PCT)鉴别弥漫性结缔组织病(CTD)患者合并细菌感染和疾病活动的意义与价值。方法:收治CTD患者128例,分两组。检测并比较细菌感染组与非感染组患者的红细胞沉降率(ESR)、C反应蛋白(CRP)、PCT水平。结果:感染组患者的PCT、CRP与ESR值显著高于非感染组(P<0.05)。采用ROC曲线评估ESR、CRP、PCT诊断CTD患者的细菌感染与疾病活动,ESR界值是43.28 mm/h,CRP界值7.12 mg/L,PCT界值0.22 ng/m L。PCT鉴别方法的效能均显著高于ESR与CRP鉴别方法(P<0.05)。结论:CTD细菌感染患者的PCT水平与患者感染的严重程度正相关,采用PCT动态监测鉴别抗感染的疗效准确度高。

Objective:To evaluate the significance and value of plasma calcitonin(PCT)in identifying patients with diffuseconnective tissue disease(CTD)complicated with bacterial infection and disease activity.Methods:128 patients with CTD wereselected,they were divided into the two groups.The erythrocyte sedimentation rate(ESR),C reactive protein(CRP)and PCT levelswere detected and compared between the bacterial infection group and the non infected group.Results:The value of PCT,CRP andESR in the infection group were significantly higher than those in the non infection group(P<0.05).Using ROC curves to assessESR,CRP,PCT to diagnose bacterial infections and disease activity in patients with CTD,the boundary value of ESR was 43.28mm/h,CRP boundary value was 7.12 mg/L,PCT boundary value was 0.22 ng/mL.The efficiency of PCT identification method wassignificantly higher than that of ESR and CRP(P<0.05).Conclusion:The level of PCT in patients with CTD bacterial infection ispositively correlated with the severity of the infection,the efficacy of PCT dynamic monitoring in the identification of anti infectionis high.