炎症与肿瘤的关系研究进展

Progress in Study of Interaction Between Inflammation and Tumor

炎症反应不仅诱导肿瘤的发生,并且促进肿瘤的发展及转移。在炎症尤其是慢性炎症中,炎症细胞会诱导细胞内产生ROS,引起氧化应激反应,致使DNA损伤并抑制损伤后修复,使抑癌基因发生突变,导致肿瘤的发生;肿瘤微环境中存在的大量炎症细胞和炎症因子会诱导多种细胞因子以及趋化因子的表达,促使细胞增殖并诱导血管生成,从而促进肿瘤的发展及转移。此外,以炎症微环境为靶向的药物在肿瘤治疗中起到了一定的作用,也表明炎症与肿瘤的发生、发展密切相关。综述了炎症与肿瘤的发生、发展及转移之间的相互关系,旨在为肿瘤治疗提供新方向。

The inflammatory response not only induces the initiation of tumor,but also promotes tumor development and metastasis. Recent data have shown that inflammation, especially chronic inflammation,induces ROS production and consequently causes oxidative stress response,resulting in DNA damage and repair- inhibition after cellular damage. The accumulation of damage can induce mutations in tumor suppressor genes and finally cause tumorigenesis. Meanwhile,there are many inflammatory cells and inflammatory factors in the tumor micro-environment,induce angiogenesis and tumor progression through up-regulation of the expression of multiple cytokines and chemokines. In addition,some drugs targeting the tumor micro-environment have been shown to be effective in tumor treatments,indicating that inflammation is closely related to tumor occurrence and development. This review summarizes the relationship between inflammation and tumor,with the aim of providing a new treatment option for tumor.