卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫的临床效果评价

Clinical effect evaluatation of carbamazepine,topiramate and sodium valproate in the treatment of encephalitis with secondary epilepsy

目的:探讨卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫的临床效果。方法:收治脑炎继发癫痫患者66例,分为3组。A组给予卡马西平治疗,B组给予托吡酯治疗,C组给予丙戊酸钠治疗,比较3组临床疗效及不良反应发生情况。结果:3组总有效率比较,差异无统计学意义(P>0.05)。B组不良反应发生率明显低于A组和C组,差异具有统计学意义(P<0.05)。结论:卡马西平和托吡酯与丙戊酸钠均能够有效治疗脑炎继发癫痫,托吡酯因不良反应较低,更适用于临床治疗脑炎继发癫痫。

Objective:To investigate the clinical effect of carbamazepine,topiramate and sodium valproate in the treatment of encephalitis with secondary epilepsy.Methods:66 cases of patients with encephalitis with secondary epilepsy were divided into three groups.A group was treated with carbamazepine;B group was treated with topiramate;C group was treated with sodium valproate.The clinical curative effect and adverse reaction of three groups were compared.Results:There was no significant difference of the total effective rate in the three groups (P>0.05).The incidence of adverse reactions in B group was significantly lower than that in A group and C group,and the difference was statistically significant (P<0.05).Conclusion:Carbamazepine,topiramate and sodium valproate could treat encephalitis with secondary epilepsy effectively and topiramate was more suitable for the clinical treatment of encephalitis with secondary epilepsy due to less adverse reaction.