N末端脑钠肽在心功能不全分级诊断中的应用

Application of N terminal brain natriuretic peptide in the classification diagnosis of cardiac insufficiency

目的:研究N末端脑钠肽(NT-proBNP)在心功能不全分级诊断中的价值。方法:以104例心功能不全患者和60例体检正常者作为研究对象,比较血清NT-proBNP水平与LVEF和心功能情况的关系。结果:心功能不全患者血清NT-proBNP水平升高,随着心功能分级程度增高,NT-proBNP水平显著升高,与LVEF呈负相关;不同病因中,扩张性心肌病、冠心病和高血压性心脏病NT-proBNP与LVEF有相关性;NT-proBNP以300 pg/L为参考值对心功能不全的诊断敏感度96.2%,特异度95%。结论:NT-proBNP的水平能够帮助心功能不全的诊断和分级,反映心脏血流动力学情况,但是不能完全反映出不同病因所致心功能不全的情况。

Objective:To study the value of N terminal brain natriuretic peptide(NT-proBNP) in the classification diagnosis of cardiac insufficiency.Methods:104 patients with cardiac insufficiency and 60 cases of normal physical examinees were as the study objects.The relationship between serum NT-proBNP levels and LVEF and cardiac function were compared.Results:The serum NT-proBNP level was increased in patients with cardiac insufficiency,and with the increase of the degree of cardiac function,the NT-proBNP level was significantly increased,and it negatively correlated with LVEF.In different etiologies,the NT-proBNP and LVEF had correlation in dilated cardiomyopathy,coronary heart disease and high blood pressure heart disease.The NT-proBNP 300 pg/L was as the reference value,the sensitivity in the diagnosis of cardiac insufficiency was 96.2% ,the specificity was 95%.Conclusion:The NT-proBNP level can help the diagnosis and classification of cardiac insufficiency,reflects the cardiac hemodynamics,but can not completely reflect the different causes of cardiac insufficiency.