HE4对卵巢恶性肿瘤鉴别及与病理特征的关系研究

Study on the identification of malignant ovarian tumor and relationship between HE4 and pathological characteristics

目的:探讨人附睾蛋白4(HE4)对卵巢恶性肿瘤鉴别及与病理特征的关系。方法:收治卵巢肿瘤患者210例,分为观察1组、观察2组。选取健康女性100例作为对照组。检测3组的血清HE4水平。结果:观察1组血清HE4水平明显高于观察2组、对照组,差异具有统计学意义(P<0.05)。观察2组血清HE4水平与对照组间相比,差异无统计学意义(P>0.05)。低分化级阳性率高于中高分化级阳性率,早期卵巢癌阳性率低于晚期卵巢癌阳性率,差异具有统计学意义(P<0.05)。结论:HE4是较好的诊断卵巢恶性肿瘤的标志物,其水平与病理特征具有一定的相关性。

Objective:To investigate the identification of malignant ovarian tumor and relationship between HE4 and pathological characteristics.Methods:210 cases of patients with ovarian tumor were divided into the observation group 1 and the observation group 2.100 cases of healthy women were as the control group.The serum HE4 levels in the three groups were detected.Results:The serum HE4 level of the observation group 1 was significantly higher than that of the observation group 2 and the control group,and the differences were statistically significant (P<0.05).There was no significant difference between the observation group 2 and the control group (P>0.05).The positive rate of the low differentiation grade was higher than that of the middle and high differentiation grade,and the positive rate of early ovarian cancer was lower than that of the advanced ovarian cancer,and the difference was statistically significant (P<0.05).Conclusion:HE4 was good marker for diagnosis of malignant ovarian tumor,and its level had a certain correlation with pathological characteristics.