进展期胃癌患者前白蛋白水平与PG-SGA评分相关性分析

The correlation between prealbumin levels and PG-SGA score in patients with advanced gastric cancer

目的比较分析进展期胃癌患者血清PA水平和PG-SGA评分之间的关系,探讨更为科学的进展期胃癌患者营养评估方法。方法选取山西省人民医院普外科2015年5月1日至2016年5月1日期间收治的可根治性切除进展期胃癌患者72例,运用PG-SGA量表进行营养评估,同时测定空腹静脉血清PA水平,采用Spearman相关系数法分析PA水平与PGSGA评分之间的相关性。结果 72例进展期胃癌患者中,营养不良(PG-SGA≥4分)患者48例,占67%;营养不良患者PA平均水平为152.57±46.95mg/L,明显低于非营养不良患者的252.68±44.31mg/L(P<0.001);PA水平越高,PG-SGA分值越低。PG-SGA评分≥4分的PA临界值为186.82 mg/L(P<0.001)。结论进展期胃癌患者有较高的营养不良发生率;其PA水平与PG-SGA评分存在负相关关系,当PA水平低于186.82mg/L时,患者存在营养不良(PG-SGA≥4分)。PA水平测定和PG-SGA评分相结合可更准确地评估进展期胃癌患者营养状况。

Objective To probe a more scientific nutritional assessment tool for patients with advanced gastric carcinomaby comparing and analyzing the relationship between PA levels and PG-SGA score. Methods 72 patients with advanced gastriccarcinoma and suitable for radical resection were enrolled in this study by the Department of General Surgery in Shanxi People'sHospital from May 1, 2015 to May 1, 2016. PG-SGA was applied for nutritional status evaluation, venous serum PA levels wasmeasured for protein level, and the Spearman correlation coefficient method was used to analyze the correlation between PA levelsand PG-SGA score. Results Among the 72 advanced gastric carcinoma patients, 48 cases (67%) were in malnutrition (PG-SGA≥4)with a PA levels at 152.57±46.95mg/L, significantly lower than the non-malnutrition group (252.68±44.31mg/L, P<0.001); Thehigher PA levels was, the lower PG-SGA score got, the cut-point PA levels was 186.82mg/L when the PG-SGA score was equal/higher than 4 points (P<0.001). Conclusions The incidence of malnutrition in patients with advanced gastric carcinoma was high;the results of this study confirmed that PA levels and PG-SGA score had a negative correlation, when the PA levels was lowerthan 186.82mg/L, the patients were malnourished. The combination of PA levels and PG-SGA score could provide comprehensiveassessment of the nutritional status for patients with advanced gastric carcinoma.