精氨酸脱敏牙膏治疗牙本质敏感的Meta分析

Arginine-containing desensitization toothpaste for dentin hypersensitivity:a Meta analysis

目的采用Meta分析方法进行系统评价并比较精氨酸脱敏牙膏与常用脱敏牙膏治疗牙本质敏感的疗效。方法计算机检索万方、Pub Med、Web of Science和Cochrane图书馆等数据库,并辅以手工检索,搜集精氨酸脱敏牙膏治疗牙本质敏感的随机对照试验(randomized controlled trial,RCT),数据的提取和质量评价由两个评价者独立完成。采用Rev Man 5.3软件进行Meta分析。结果共纳入7项RCT,所有的结果通过触压敏感测试及冷空气喷吹检测评估,使用随机效应模型分析各治疗组的均数和标准差。Meta分析结果显示,精氨酸脱敏牙膏与含钾脱敏牙膏的疗效差异有统计学意义(触压评估:SMD=1.83,95%CI[1.07,2.58],P<0.05;冷空气评估:SMD=-1.19,95%CI[-1.69,-0.69],P<0.05);精氨酸脱敏牙膏与含锶脱敏牙膏的疗效差异无统计学意义(触压评估:SMD=0.68,95%CI[-1.59,2.96],P>0.05;冷空气评估:SMD=-0.94,95%CI[-2.28,0.40],P>0.05)。结论精氨酸脱敏牙膏治疗牙本质敏感的效果优于含钾脱敏牙膏,但与含锶脱敏牙膏无明显差异。

Objective Meta analysis was used to evaluate and compare the efficacy of treatment of dentin hypersensitivity with arginine desensitization toothpaste and commonly used desensitization toothpaste. Methods A computerized search of Wanfang, PubMed, web of science, and Cochrane library databases was performed, and a manual retrieval was supplemented. Randomized control trials (RCT) about arginine-containing desensitization toothpaste for dentine hypersensitivity were collected, then data extraction and quality assessment were performed by 2 raters independently. Meta-analysis was carried out by RevMan 5.3 software. Results A total of 7 RCTs were included. All the results were evaluated by the tactile sensitivity test and the air blast test. The mean and standard deviation of each treatment group were analyzed by the random effects model. Meta?analysis results showed there was statistical significance in the therapeutic effects between arginine-containing desensitization toothpaste and potassium?containing desensitization toothpaste(tactile sensitivity test to evaluate: SMD = 1.83, 95% CI BP, 2.58], P < 0.05; cold air assessment: SMD = ?1.19, 95% CI[-1.69, ?0.69], P < 0.05); However, there was no statistical significance between arginine?containing desensitization toothpaste and strontium?containing desensitization toothpaste (tactile sensitivity test to evaluate: SMD = 0.68, 95% CI[?1.59, 2.96], P > 0.05; cold air assessment: SMD = -0.94, 95% CI [?2.28, 0.40], P > 0.05). Conclusion It shows that arginine-containing desensitization toothpaste has greater effects than potassium?containing desensitization toothpaste for dentin hypersensitivity, but no better effects than strontium?containing desensitization toothpaste.