α-干扰素治疗丙肝的临床效果观察

Observation on the clinical effects of α-interferon in the treatment of patients with hepatitis C

目的：探究α-干扰素治疗丙肝的临床效果。方法：收治丙肝患者78例，按照年龄阶段的不同进行分组，给予α-干扰素进行治疗，对比、分析临床疗效的异同。结果：对比4个不同年龄的总有效率，24～34岁总有效率94.1%，35～44岁84.6%，45～55岁30.7%，55岁以上22.7%，年龄越大，应用α-干扰素治疗丙肝患者的临床疗效越低，组间进行比较，差异有统计学意义(P＜0.05)。病理分期越重，临床有效率越差。结论：患者的年龄大小、病理分期的轻重都会影响α-干扰素治疗丙肝的临床效果，及时、尽早地在明确丙肝诊断后积极应用治疗α-干扰素，对临床有效率及预后具有重要意义。

Objective:To investigate the clinical effects of α-interferon in the treatment of patients with hepatitis C.Methods:78 patients with hepatitis C were selected.All patients were grouped according to different age.They were all treated byα-interferon.We compared and analyzed the similarities and differences of clinical efficacy.Results:We compared the total effective rate of 4 different ages;the total effective rate of 24～34 years old was 94.1%;35～44 years old was 84.6%;45～55 years old was 30.7%;over 55 years old was 22.7% ;the elder the age,the lower the curative effect of α-interferon in the treatment of patients with hepatitis C,comparison between groups,and the differences were statistically significant(P<0.05).The more severer of pathological stage,the worse of clinical efficiency.Conclusion:The severity of age and pathological staging of the patients will affect the clinical effect of interferon therapy for hepatitis C.α-interferon should be actively applied after clearly and timely diagnosis of hepatitis C as soon as possible,which has important significance on the prognosis and clinical efficiency.