奥氮平治疗精神分裂症42例临床分析

Analysis of olanzapine in the treatment of 42 patients with schizophrenia

目的:了解奥氮平治疗精神分裂症的疗效和安全性。方法:奥氮平治疗精神分裂症42例,于治疗前及治疗8周末采用简明精神病量表、阳性和阴性症状量表(PANSS)评定临床疗效。结果:治疗8周末,显效率79.74%,有效率达95%。并随着治疗时间的延续均呈持续性下降。不良反应为胆碱能作用、嗜睡、体重增加和一过性肝酶升高等。结论:奥氮平治疗精神分裂症疗效显著,起效快,安全性高,依从性好。

Objective:To study the efficacy and safety of olanzapine in treatment of schizophrenia.Methods:42 patients with schizophrenia were treated by olanzapine.The clinical efficacy was assessed with the brief psychiatric rating scale,positive and negative symptom scale(PANSS)before treatment and at the end of 8 weeks.Results:At the end of 8-week therapy,the markedly effective rate was 79.74% ,and the effective rate was 95% ,with time and continued therapy showed a persistent decline.The adverse effects were cholinergic effect,sleepiness,weight gain,and transient liver enzyme elevation.Conclusion:Olanzapine in treatment of schizophrenia has obvious curative effect,fast acting,with high safety and good compliance.