盐酸羟考酮注射液用于门诊无痛胃肠镜检查及治疗的临床观察

The clinical observation of oxycodone hydrochloride injection for painless endoscopes

目的:观察盐酸羟考酮复合丙泊酚用于门诊无痛胃肠镜的麻醉效果。方法:门诊ASAⅠ-Ⅱ级无痛胃肠镜检查及治疗的患者96例,随机分为2组,即丙泊酚复合盐酸羟考酮组(A组)45例、丙泊酚复合芬太尼组(B组)51例,记录入室后(T1)、置镜前(T2)、镜子完全置入即刻(T3)、出镜后(T4)4个时间点的MAP、HR、RR、SPO2及意识恢复时间、呼吸抑制发生率、恶心呕吐发生率、体动例数、检查结束15min后Ramsay评分,丙泊酚用量等。结果:两组在4个时间点HR相比均无显著性差异(P>0.05),两组MAP在T2,T3及T4时间点与T1时间点相比均具有显著性差异(P<0.05)。B组的RR、SPO2在T3时间点与T1时间点相比具有显著性差异(P<0.05),与A组T3时间点相比也具有显著性差异(P<0.05)。A组与B组相比意识恢复快,丙泊酚用量少,呼吸抑制发生少,镇静镇痛效果好。结论:丙泊酚复合盐酸羟考酮可安全用于门诊无痛胃肠镜检查及治疗。

Objective:To observe the clinical effect of Propofol combined with oxycodone hydrochloride injection in painless endoscopes. Methods:Ninety six patients in ASA I and II,planned for painless endoscopes,were included in the study. Subjects were randomly divided into two groups : Propofol combined with oxycodone administrated intrave- nousl was group A,and propofol combined with fentanyl infusion was group B. All the subjects were monitored and re-corded MAP, HR, RR and SP02 after enter into endoscope room ( T1) , before endoscopes putting ( T2 ) , during endo-scopes putting ( T3 ) and after endoscopes taking out ( T4 ) . The waking time, respiratory depression occurrence, body movement,Ramsay scale, nausea and vomiting occurrence and dosage of propofol were recorded. Results: MAP de-creased significantly on T2, T3 and T4 compared with that of on T1 ( P < 0. 05 ) . RR and SP02 in group B had signifi-cant difference on T3 compared with that on T1, and also had significant difference compared with group A on T3 time point (P <0. 05) . The dose of propofol, waking time and respiratory depression in group A were decreased significantly campared with group B ( P < 0. 05 ) . The Ramay scale had no significant difference between the groups (P > 0. 05 ). There was no patient occurring nausea and vomiting in both groups. Conclusion : Propofol combined with oxycodone hydrochloride injection for painless endoscopes could decrease propofol dosage, avoid respiratory depression and de-curtate waking time.