丹蛭降糖胶囊对糖尿病合并高血压患者E-选择素、趋化因子-9的影响

The effect of Danzhijiangtang Capsule on serum E-selectin and CXCL-9 in diabetic mellitus patients with hypertension

目的观察丹蛭降糖胶囊对糖尿病合并高血压患者趋化因子-9(CXCL-9)和E-选择素的影响。方法选择糖尿病合并高血压患者60例,其中服用丹蛭降糖胶囊加西药者30例(简称丹蛭组),单用西药者30例(简称西药组),两组均连续服药3个月。另选取在医院健康体检者30例为健康对照组。三组均行血糖、血脂、糖化血红蛋白检测,采用ELISA法检测患者血清CXCL-9、E-选择素水平,测定各组血压、体质量指数(BMI)。结果丹蛭组收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后血糖(2h PG)、糖化血红蛋白(Hb A1c)、低密度脂蛋白胆固醇(LDL-C)均显著高于健康对照组(P<0.01或P<0.05);丹蛭组与西药组比较,BMI、Hb A1c、TG、TC、HDL-C、LDL-C差异均无统计学意义(P>0.05)。两组与健康对照组比较CXCL-9、E-选择素明显升高(P<0.01);丹蛭组与西药组比较CXCL-9、E-选择素差异均有统计学意义(P<0.01或P<0.05)。结论丹蛭降糖胶囊可降低糖尿病高血压患者血清E-选择素、CXCL-9水平,E选择素、CXCL-9可能共同参与了糖尿病高血压病的炎性反应过程。

O b je c tiv e To observe t2e effects o f D anzhijiangtang Capsule ( D J C ) on serum E -se le ctin andC X C L -9 in d ia b e tic m e llitu s patients w ith hypertension. M e th o d s S ixty diabetes m e llitu s patients w ith hypertensionwere random ly d ivid e d in to two group : DJC group ( n = 3 0 ) and western m e dicine con trol group ( n = 3 0 ) . fo r 3 m ouths. T h irty he althy cases were sleeted as con trol group. The blood gluco se, blood lip id , glycosylated hemoglo b in ( H b A 1c ) , blood pre ssu re ,b o d y mass in d e x ( B M I) and E -s e le c tin ,C X C L -9 were m easured. R e s u lts The systolicpressure ( S B P ) ,dia sto lic blood pressure ( D B P ) ,fastin g blood glucose ( F P G ) ,po stpra ndial blood glucose j H b A ^ ,de nsity lip o p ro te in c h o le s te ro l L D L -C ) in DJC group were h ig h e r than those in the con trol g r o u p ( P < 0 . 01 0 5 ) . A n d there was no statistica l significance o f B M I,H b A 1c , T G ,T C ,H D L -C ,L D L - C ( P > 0 . 0 5 ) bet^veen two groups.The le ve l o f E -se le ctin and C X C L -9 in DJC + western m e dicine group were h ig h e r than control group ( P < 0. 0 1 ) . Thediffe ren ce was s ig n ific a n t P < 0. 01 or P < 0. 05 ) . A n d the H b A 2 c was p o s itiv e ly correlated w ith E -se le ctin and C X C L -9 in two groups. C on clu sion DJC cou ld reduce the le ve l o f E -s e le c tin and C X C L -9 in d ia b e tic m e llitu s patients w ithhypertension. The effica cy o f DJC group is be tter than western m e dicine group. I t is suggest th a t m ay p a rticip a te in the in fla m m a tio n process o f d ia b e tic m e llitu s and hypertension disease.