亚甲基四氢叶酸还原酶基因A1298C多态性与帕金森病易感性的Meta分析

Meta-analysis on methlenetetrahydrofolate reductase gene polymorphisms and Parkinson's disease susceptibility

目的探讨亚甲基四氢叶酸还原酶（MTHFR)基因A1298C位点单核苷酸多态性（SNP)与帕金森病（PD)易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方数据库、维普信息资源系统，PubMed、CochraneLibrary、〇vidSP、WileyOnlineLibrary、SpringerLink、EBSCO、ElevierScienceDictGooglescholar数据库检索MTHFR基因A1298C位点SNP与PD相关的病例对照研究，利用RevMan5.3和Stata12.0软件，根据异质性大小选用随机效应或固定效应模型对各研究数据进行分析。结果共纳入8篇文献。蚧^1分析结果提示卩0组和对照组人人基因型[0没=0.92,95%?/:0.78~1.09，/3=0.33]和〔〔基因型[0没=1.19,95%?/:0.89~1.59，/3=0.23]、人等位基因[0没=0.92,95%?/:0.81~1.04，/3=0.19]和〔等位基因[〇穴=1.09,95%a:0.96~1.24，P=0.19]差异均无统计学意义。

Objective To explore the association between A1298C polymorphism of methlenetetrahydrofolatereductase (MTHFR) gene and Parkinsons disease (PD) susceptibility. Methods The case-control studies of MTHFRgene and PD were selected from Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wanfang,Weipu,PubMed, Cochrane Library, OvidSP, Wiley Online Library, EBSCO, Elsevier Science Direct, Springer Link andGoogle scholar databases. The study data were analysed by random - effects or fixed - effects models depending on heter-ogeneity use RevMan 5. 3 and Stata 12. 0 software. Results Eight articles were included. The meta - analysis resultssuggested that there were no significant differences in genotype AA[ OR =0.92,95% Cl: 0. 78 - 1.09 = 0. 33 ] ,geno-type CC[ OR = 1.19,95% Cl: 0.89 - 1.59,P= 0.23] ,allele A[OR = 0.92,95% Cl : 0.81 - 1.04,P =0.19] and al-lele C [ OR = 1.09,95% Cl: 0. 96 - 1.24 = 0. 19 ] between PD group and control group. Conclusion No relationshipis found between the A1298C polymorphism of MTHFR gene and PD susceptibility.