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ARTN在恶性肿瘤发生发展中的作用研究进展 被引量：2

Roles of ARTN in the development of malignant tumors
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摘要 ARTN(Artemin)又名ENOVIN,是胶质细胞源神经营养因子(glial cell line-derived neurotrophic factor,GDNF)配体家族成员之一,ARTN及其受体GFRα3(GDNF family receptor alpha-3,GFRα3)在一些恶性肿瘤中表达升高,并参与了某些恶性肿瘤的发生发展,研究ARTN及其受体GFRα3在恶性肿瘤中的作用,或许能发现恶性肿瘤新的靶点,为早期诊断和早期治疗提供帮助。本文就ARTN在恶性肿瘤中的研究进展做一综述。 ARTN ( Artemin) alias ENOVIN, is one of a member of the glial cell line-derived neurotrophic factor family of ligands.ARTN and its receptor GFRa3 expressed highly in some kinds of malignancies and maybe involved in the development of them,so it may be useful for early diagnosis and treatment based on deep understanding of the roll of ARTN and its receptor GFRa3. In thisarticle, we aimed to summarize the development of ARTN in malignancies.
作者 陈雅琪 文彬 CHEN Ya -qi;WEN Bin(Department o f Pathology, North Sichuan Medical College ,Nanchong 631000 , Sichuan, China)
机构地区 川北医学院病理教研室
出处 《川北医学院学报》 CAS 2016年第3期439-442,共4页 Journal of North Sichuan Medical College
基金 南充市研发资金项目(15A0037)
关键词 ARTN GFRa3 恶性肿瘤 ARTN GFRa3 Malignancy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献25

  • 1Baloh RH,Tansey MG,Lampe PA,et al.Artemin,a novel member of the GDNF ligand family,supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex[J].Neuron,1998,21(6):1291-1302.
  • 2Baloh RH,Tansey MG,Johnson EM Jr,et al.Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor(GDNF)family ligands and production of GFRalphal RET-specific agonists[J]-J Biol Chem,2000,275(5):3412-3420.
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二级参考文献35

  • 1Pandey V,Jung Y,Kang J,et al. Artemin reduces sensitivity to doxorubicin and paclitaxed in endometrial carcinoma cells through specific regulation of CD24[J]. Transl Oncol, 2010, 3(4):218-229.
  • 2Tang JZ, Kong XJ, Kang J, et al. Artemin-stimulated progression of human non-small cell lung carcinoma is mediated by BCL-2[J]. Mol Cancer Ther,2010,9(6) :1697-1708.
  • 3Kang J,Perry JK,Pandey V,et al. Artemin is oncogenic for human mammary carcinoma cells [J]. Oncogene, 2009,28 (19) 2304-2045.
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  • 10Jankowski MP,Rau KK,Soneji DJ,et al.Enhanced artemin/GFRα3 lev-els regulate mechanically insensitive,heat-sensitive C-fiber recruitment af-ter axotomy and regeneration[J].J Neurosci,2010;30(48):16272-83.

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川北医学院学报
2016年 第3期

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